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學歷 |
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國別 |
畢 / 肄業學校 |
主修學門系所 |
學位 |
起訖年月 |
|
美國 |
加州大學柏克萊校區 |
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博士 |
1973年 |
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中華民國 |
國立台灣大學 |
醫學院 |
學士 |
1968年 |
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現職 |
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服務機關
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服務部門/系所
|
職稱
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國立成功大學 |
校長室 |
校長 |
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經歷 |
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服務機關
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服務部門/系所
|
職稱
|
起訖年月
|
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中央研究院分子生物研究所 |
特聘研究員兼副院長 |
2003年~2006年 |
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美國霍華休斯醫學協會 |
正研究員 |
1990年~2003年 |
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中央研究院 |
訪問教授 |
1988年 |
|
美國南加州大學 |
卓越教授 |
2002年~2007年 |
|
美國南加州大學 |
教授 |
1983年~2002年 |
|
美國南加州大學 |
副教授 |
1978年~1983年 |
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美國南加州大學 |
助理教授 |
1973年~1978年 |
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專長 |
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學術獎勵、榮譽事項 |
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發展中世界科學院院士(2006) |
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美國科學資訊所公佈從1981年~2000年論文最被高度引用的研究者(2004) |
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國立中央大學名譽博士(2003) |
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台美基金會科技工程人才成就獎(2002) |
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美戰南加洲大學傑出教授(2002) |
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美國微生物學院院士(2002) |
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美國南加大協會學術成就與研究創新獎(1998) |
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中央研究院院士(1992) |
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美洲華人生物科學家學會-國泰醫肝炎研究獎(1990) |
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北柏林頓基金會傑出學者獎(1989) |
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研究著作(最近三年) |
|
Kawamura H, Govindarajan
S, Aswad F, Machida K, Lai MM, Sung VM, Dennert
G. (2006) HCV core expression in hepatocytes
protects against autoimmune liver injury and
promotes liver regeneration in mice. Hepatology.
44, 936-44. |
|
Macnaughton TB, Lai MM.
(2006) HDV RNA replication: ancient relic or
primer? Curr Top Microbiol Immunol. 307, 25-45.
Review. |
|
Machida K, Cheng KT, Lai
CK, Jeng KS, Sung VM, Lai MM. (2006) Hepatitis C
virus triggers mitochondrial permeability
transition with production of reactive oxygen
species, leading to DNA damage and STAT3
activation. J Virol. 80, 7199-207. |
|
Li YJ, Macnaughton T, Gao
L, Lai MM. (2006) RNA-templated replication of
hepatitis delta virus: genomic and antigenomic
RNAs associate with different nuclear bodies. J
Virol. 80, 6478-86. |
|
Yu GY, Lee KJ, Gao L, Lai
MM. (2006) Palmitoylation and polymerization of
hepatitis C virus NS4B protein. J Virol. 80,
6013-23. |
|
Choi SH, Park KJ, Ahn BY,
Jung G, Lai MM, Hwang SB. (2006) Hepatitis C
virus nonstructural 5B protein regulates tumor
necrosis factor alpha signaling through effects
on cellular IkappaB kinase. Mol Cell Biol. 26,
3048-59. |
|
Lee J, Wu CC, Lee KJ,
Chuang TH, Katakura K, Liu YT, Chan M, Tawatao
R, Chung M, Shen C, Cottam HB, Lai MM, Raz E,
Carson DA. (2006) Activation of anti-hepatitis C
virus responses via Toll-like receptor 7. Proc
Natl Acad Sci U S A. 103, 1828-33. |
|
Machida K, Cheng KT, Sung
VM, Levine AM, Foung S, Lai MM. (2006) Hepatitis
C virus induces toll-like receptor 4 expression,
leading to enhanced production of beta
interferon and interleukin-6. J Virol. 80,
866-74. |
|
Lai MM. (2005) RNA
replication without RNA-dependent RNA
polymerase: surprises from hepatitis delta
virus. J Virol. 79, 7951-8. Review. |
|
Hamamoto I, Nishimura Y,
Okamoto T, Aizaki H, Liu M, Mori Y, Abe T,
Suzuki T, Lai MM, Miyamura T, Moriishi K,
Matsuura Y. (2005) Human VAP-B is involved in
hepatitis C virus replication through
interaction with NS5A and NS5B. J Virol. 79,
13473-82. |
|
ChoiKS, Aizaki H, Lai MM.
(2005) Murine coronavirus requires lipid rafts
for virus entry and cell-cell fusion but not for
virus release. J Virol.79, 9862-71. |
|
Machida K, Cheng KT, Pavio
N, Sung VM, Lai MM.(2005) Hepatitis C virus
E2-CD81 interaction induces hypermutation of the
immunoglobulin gene in B cells. J Virol. 79,
8079-89. |
|
Shi S.T., Lai M.M.C.
(2005) Viral and cellular proteins involved in
coronavirus replication. Curr. To.p Microbiol.
Immunol. 287, 95-131. Review. |
|
Yu G.Y., Lai M.M.C. (2005)
The ubiquitin-proteasome system facilitates the
transfer of murine coronavirus from endosome to
cytoplasm during virus entry. J. Virol. 79,
644-648. |
|
Lai, M.M.C. (2005) RNA
replication without RNA-dependent RNA
polymerase: Surprises from hepatitis delta
virus. J. Virol. (minireview) 79, 7951-7958. |
|
Choi K.S., Mizutani A.,
Lai M.M.C. (2004) SYNCRIP, a member of the
heterogeneous nuclear ribonucleoprotein family,
is involved in mouse hepatitis virus RNA
synthesis. J. Virol. 78, 13153-13162. |
|
Vo N.V., Tuler J.R., Lai
M.M.C. (2004) Enzymatic characterization of the
full-length and C-terminally truncated hepatitis
C virus RNA polymerases: function of the last 21
amino acids of the C terminus in template
binding and RNA synthesis. Biochemistry 43,
10579-10591. |
|
Machida K., Cheng K.T.,
Sung V.M., Lee K.J., Levine A.M., Lai M.M.C.
(2004) Hepatitis C virus infection activates the
immunologic (type II) isoform of nitric oxide
synthase and thereby enhances DNA damage and
mutations of cellular genes. J. Virol. 78,
8835-8843. |
|
Aizaki H., Lee K.J., Sung
V.M., Ishiko H., Lai M.M.C. (2004)
Characterization of the hepatitis C virus RNA
replication complex associated with lipid rafts.
Virology 324, 450-461. |
|
Lee K.J., Choi J., Ou J.H.,
Lai M.M.C. (2004) Interactions between viral
nonstructural proteins and host protein hVAP-33
mediate the formation of hepatitis C virus RNA
replication complex on lipid raft. J Virol. 78,
3480-3488. |
|
Machida K., Cheng K.T.,
Sung V.M., Shimodaira S., Lindsay K.L., Levine
A.M., Lai M.Y., Lai M.M.C. (2004) Hepatitis C
virus induces a mutator phenotype: enhanced
mutations of immunoglobulin and protooncogenes.
Proc. Natl. Acad. Sci. U S A 101, 4262-4267. |
|
Li Y.J., Stallcup M.R.,
Lai M.M.C. (2004) Hepatitis delta virus antigen
is methylated at arginine residues, and
methylation regulates subcellular localization
and RNA replication. J Virol. 78, 13325-13334.
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